Valsartan provides effective antihypertensive response in older patients: An integrated analysis
نویسندگان
چکیده
منابع مشابه
Response to Antihypertensive Therapy in Older Patients With Sustained and Nonsustained Systolic Hypertension
Robert H. Fagard, MD; Jan A. Staessen, MD; Lutgarde Thijs, BSc; Jerzy Gasowski, MD; Christopher J. Bulpitt, MD; Denis Clement, MD; Peter W. de Leeuw, MD; Jurij Dobovisek, MD; Matti Jääskivi, MD; Gastone Leonetti, MD; Eoin O’Brien, MD; Paolo Palatini, MD; Gianfranco Parati, MD; José L. Rodicio, MD; Hannu Vanhanen, MD; John Webster, MD; for the Systolic Hypertension in Europe (Syst-Eur) Trial Inv...
متن کاملAliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients.
BACKGROUND Stopping the detrimental effects of the renin-angiotensin system at the most upstream point of the cascade offers theoretical advantages for cardiovascular protection. This study compares the antihypertensive efficacy and safety of the novel oral renin inhibitor aliskiren with placebo and an active comparator. METHODS AND RESULTS The study was a randomized, multicenter, double-blin...
متن کاملThe Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) trial: outcomes in patients receiving monotherapy.
In the main Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) report, we investigated outcomes in 15 245 high-risk hypertensive subjects treated with valsartan- or amlodipine-based regimens. In this report, we analyzed outcomes in 7080 patients (46.4%) who, at the end of the initial drug adjustment period (6 months), remained on monotherapy. Baseline characteristics were similar in th...
متن کاملSustained antihypertensive activity of telmisartan compared with valsartan.
BACKGROUND Early morning blood pressure (BP) surge and 24 h mean BP are linked to target-organ damage and cardiovascular events. Antihypertensive agents should sustain BP control, particularly in the last 6 h of the dosing interval or if dosing is missed. The efficacies of the long half-life telmisartan compared with shorter half-life valsartan in the last 6 h of the dosing interval following a...
متن کاملOptimal timing for antihypertensive dosing: focus on valsartan
Some specific features of the 24 h blood pressure (BP) pattern are linked to the progressive injury of target tissues and the triggering of cardiac and cerebrovascular events. In particular, many studies show the extent of the nocturnal BP decline relative to the diurnal BP mean (the diurnal/nocturnal ratio, an index of BP dipping) is deterministic of cardiovascular injury and risk. Normalizati...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2000
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(00)00981-x